Alonso O, Martínez M, Lago G, Espasandin J
Nuclear Medicine Center and Department of Dermatology, Clinical Hospital of the University of Uruguay, Montevideo.
J Nucl Med Technol. 2001 Sep;29(3):152-3.
Previous reports have shown that (99m)Tc-sestamibi (MIBI) could detect clinically occult metastatic melanoma lesions. This article reports on a patient with invasive melanoma of the right heel in whom the sentinel node status was preoperatively evaluated with this tracer. Although regional lymph nodes were clinically negative, (99m)Tc-MIBI scintigraphy showed focal increased tracer uptake in the right groin that corresponded to the location of 2 sentinel nodes visualized by lymphoscintigraphy with (99m)Tc-colloidal rhenium sulfide performed the same day. A gamma-probe was used intraoperatively to guide the excision of the sentinel nodes that were further classified as metastatic by histopathology. This double-technique approach is technically feasible and has the potential of selecting a group of patients who might benefit from a selective complete lymphadenectomy.
先前的报告显示，（99m）锝-甲氧基异丁基异腈（MIBI）能够检测出临床上隐匿的转移性黑色素瘤病灶。本文报道了一名右足跟侵袭性黑色素瘤患者，术前使用该示踪剂对前哨淋巴结状态进行了评估。尽管区域淋巴结临床检查为阴性，但（99m）Tc-MIBI闪烁扫描显示右腹股沟区有局灶性放射性摄取增加，这与同日进行的硫化铼胶体（99m）Tc淋巴闪烁扫描所显示的2个前哨淋巴结位置相对应。术中使用γ探测器引导前哨淋巴结切除，术后经组织病理学检查进一步确定为转移性。这种双技术方法在技术上是可行的，有可能筛选出一组可能从选择性完全淋巴结清扫术中获益的患者。
