Wong F, Blendis L
Department of Medicine, Division of Gastroenterology, Toronto General Hospital, University of Toronto, Ontario, Canada.
Clin Liver Dis. 2001 Aug;5(3):819-32. doi: 10.1016/s1089-3261(05)70193-8.
Advances in the understanding of the pathophysiology of sodium retention and ascites formation in cirrhosis has helped improve the treatment of ascites in these patients. It is likely that further unraveling of these pathophysiologic changes will lead to the development of novel and better treatment options. For example, the development of aquaretic agents for the management of hyponatremia in cirrhosis may allow more effective use of diuretic therapy. The ultimate challenge is to use the understanding of the pathophysiology to develop new strategies to prevent the development of ascites in cirrhosis.
对肝硬化患者钠潴留和腹水形成病理生理学认识的进展，有助于改善这些患者腹水的治疗。进一步阐明这些病理生理变化很可能会带来新的、更好的治疗选择。例如，开发用于治疗肝硬化低钠血症的利水药物可能会使利尿剂治疗得到更有效应用。最终的挑战是利用对病理生理学的认识来制定新策略，以预防肝硬化腹水的发生。
