• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

激素对人乳腺癌短期器官培养物影响的评估。

An assessment of the effects of hormones on short term organ cultures of human breast carcinomata.

作者信息

Beeby D I, Easty G C, Gazet J C, Grigor K, Neville A M

出版信息

Br J Cancer. 1975 Mar;31(3):317-28. doi: 10.1038/bjc.1975.66.

DOI:10.1038/bjc.1975.66
PMID:1156517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009428/
Abstract

Twenty-eight mammary carcinomata were maintained in organ culture in the presence of various hormones. The effects of the hormones have been assessed histologically by estimation of total dehydrogenases activity of the pentose glycolytic pathway and by the incorporation of tritiated thymidine or uridine into DNA or RNA. No significant effects on tumour cell activity due to hormones have been observed.

摘要

28个乳腺癌组织在多种激素存在的情况下进行器官培养。通过估计戊糖糖酵解途径的总脱氢酶活性以及将氚标记的胸腺嘧啶核苷或尿苷掺入DNA或RNA中，从组织学角度评估了激素的作用。未观察到激素对肿瘤细胞活性有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/8f4cfdf4aa86/brjcancer00324-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/e38ea7759db7/brjcancer00324-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/a9b9547e0b6e/brjcancer00324-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/b0dabca626ab/brjcancer00324-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/8f4cfdf4aa86/brjcancer00324-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/e38ea7759db7/brjcancer00324-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/a9b9547e0b6e/brjcancer00324-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/b0dabca626ab/brjcancer00324-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c10d/2009428/8f4cfdf4aa86/brjcancer00324-0057-a.jpg

相似文献

1
An assessment of the effects of hormones on short term organ cultures of human breast carcinomata.激素对人乳腺癌短期器官培养物影响的评估。
Br J Cancer. 1975 Mar;31(3):317-28. doi: 10.1038/bjc.1975.66.
2
Effect of testosterone and estradiol-17beta on synthesis of DNA, RNA and protein in human breast in organ culture.
Int J Cancer. 1975 Jan 15;15(1):78-90. doi: 10.1002/ijc.2910150110.
3
Human breast carcinomata in organ culture: the effect of hormones.人乳腺癌的器官培养：激素的作用。
Br J Cancer. 1976 May;33(5):564-6. doi: 10.1038/bjc.1976.90.
4
An assessment of the effects of steriod hormones and antiestrogens on short-term organ culture of human endometrial carcinoma.甾体激素和抗雌激素对人子宫内膜癌短期器官培养影响的评估
Eur J Cancer (1965). 1978 Sep;14(9):931-8. doi: 10.1016/0014-2964(78)90019-1.
5
[Comparisons in vivo of the tritiated thymidine and uridine uptake by human normal and cancerous tissues].[人体正常组织与癌组织对氚标记胸腺嘧啶核苷和尿苷摄取的体内比较]
C R Seances Soc Biol Fil. 1968;162(2):505-8.
6
The metabolism of 3-H-estradiol-17 beta in human breast cancer in organ culture.人乳腺癌组织块培养中3-β-雌二醇的代谢
Eur J Cancer (1965). 1975 Mar;11(3):127-30. doi: 10.1016/0014-2964(75)90106-1.
7
Effects of estrogen and-or pituitary graft on nucleic acid synthesis of carcinogen-induced mammary tumors in rats.雌激素和/或垂体移植对致癌物诱发的大鼠乳腺肿瘤核酸合成的影响。
J Natl Cancer Inst. 1974 Apr;52(4):1219-22. doi: 10.1093/jnci/52.4.1219.
8
3H-thymidine incorporation into mammary carcinoma cells obtained by needle aspiration before and during endocrine therapy.在内分泌治疗前及治疗期间，通过针吸获取的乳腺癌细胞中3H-胸腺嘧啶核苷的掺入情况。
Acta Cytol. 1976 Mar-Apr;20(2):137-43.
9
Stimulation of DNA synthesis by human placental lactogen or insulin in organ cultures of benign human breast tumors.人胎盘催乳素或胰岛素对人良性乳腺肿瘤器官培养物中DNA合成的刺激作用。
Cancer Res. 1977 Jul;37(7 Pt 1):2257-61.
10
DNA synthesis in autonomous and hormone-responsive mammary tumors.
Cancer Res. 1970 Jan;30(1):206-10.

引用本文的文献

1
Breast cancer in a male patient with prolactinoma.一名患有泌乳素瘤的男性患者患乳腺癌。
Surg Today. 1993;23(3):251-5. doi: 10.1007/BF00309236.
2
Human breast carcinomata in organ culture: the effect of hormones.人乳腺癌的器官培养：激素的作用。
Br J Cancer. 1976 May;33(5):564-6. doi: 10.1038/bjc.1976.90.

本文引用的文献

1
Studies in histochemistry. LX. Quantitative histochemical distribution of glucose 6-phosphate and 6-phosphogluconate dehydrogenases in rat adrenal, and the influence of adrenocorticotropic hormone.组织化学研究。LX。大鼠肾上腺中6-磷酸葡萄糖脱氢酶和6-磷酸葡萄糖酸脱氢酶的定量组织化学分布，以及促肾上腺皮质激素的影响。
J Biol Chem. 1960 Oct;235:3028-31.
2
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
3
Retention of nitrogenous material in unfixed sections during incubation for histochemical demonstration of enzymes.
在酶的组织化学显示孵育过程中未固定切片中含氮物质的保留。
Nature. 1965 Sep 11;207(5002):1205-6. doi: 10.1038/2071205a0.
4
A simplified method for determination of hormones responsible for breast cancer.一种用于测定引发乳腺癌的激素的简化方法。
Gan. 1969 Feb;60(1):23-31.
5
Investigation of organ culture as an aid to the hormonal management of breast cancer.
Cancer. 1970 May;25(5):1228-33. doi: 10.1002/1097-0142(197005)25:5<1228::aid-cncr2820250531>3.0.co;2-c.
6
The use of a new grade of polyvinyl alcohol for stabilising tissue sections during histochemical incubations.一种新型聚乙烯醇在组织化学孵育过程中用于稳定组织切片的应用。
Histochemie. 1971;28(3):236-42. doi: 10.1007/BF00305680.
7
Human breast carcinoma culture: the effects of hormones.人乳腺癌培养：激素的作用
Br J Surg. 1971 Oct;58(10):732-4. doi: 10.1002/bjs.1800581005.
8
Human mammary carcinoma studied for hormone responsiveness in short term incubations.在短期培养中对人乳腺癌进行激素反应性研究。
Acta Chir Scand. 1974;140(2):95-9.
9
Survival time and treatment results of patients with disseminated breast cancer especially after adrenalectomy and hypophysectomy.转移性乳腺癌患者的生存时间及治疗结果，尤其是肾上腺切除和垂体切除术后的情况。
Oncology. 1973;28(5):385-97. doi: 10.1159/000224841.
10
Human carcinoma of the breast, in vitro: the effect of hormones. A prelininary report.人乳腺癌的体外研究：激素的作用。初步报告。
Cancer. 1971 May;27(5):1112-6. doi: 10.1002/1097-0142(197105)27:5<1112::aid-cncr2820270517>3.0.co;2-7.