沙利度胺：在姑息医学和肿瘤学中的双重益处。

Thalidomide: dual benefits in palliative medicine and oncology.

作者信息

Davis M P, Dickerson E D

机构信息

Harry R. Horvitz Center for Palliative Medicine (a World Health Organization Demonstration Project), Cleveland, Ohio, USA.

出版信息

Am J Hosp Palliat Care. 2001 Sep-Oct;18(5):347-51. doi: 10.1177/104990910101800511.

DOI:10.1177/104990910101800511

PMID:11565189

Abstract

Thalidomide is an immunomodulator, anti-angiogenic agent, anti-cytokine, and anti-integrin. Alone or in combination with other drugs, thalidomide has also demonstrated anti-cachexin and anti-neoplastic properties. Anorexia and cachexia are common symptoms of advanced cancer. Since certain cytokines also promote tumor growth, we may have a class of agents with palliative and anti-tumor benefits in combination with anti-neoplastics and anti-cytokines, such as thalidomide.

摘要

沙利度胺是一种免疫调节剂、抗血管生成剂、抗细胞因子和抗整合素。单独使用或与其他药物联合使用时，沙利度胺还表现出抗恶病质和抗肿瘤特性。厌食和恶病质是晚期癌症的常见症状。由于某些细胞因子也促进肿瘤生长，我们可能拥有一类与抗肿瘤药和抗细胞因子联合使用时具有姑息和抗肿瘤益处的药物，如沙利度胺。