Kalache K D, Ojutiku D, Nishina H, Green L R, Hanson M A
Department of Obstetrics and Gynecology, Humboldt-University Berlin-Charité School of Medicine, Berlin, Germany.
J Perinat Med. 2001;29(4):286-92. doi: 10.1515/JPM.2001.041.
We wanted to investigate whether experimental dietary manipulations during early pregnancy influence placental growth and subsequently the cardiovascular system as assessed non-invasively by ultrasonography in the sheep fetus.
21 ewes bearing singletons of uniform age were randomly assigned for the first half of pregnancy to one of the following study groups: fed 100% of their nutritional requirements (i.e. controls), global reduction in total intake by 30% (i.e. 70% global) and reduction in protein intake by 30% (i.e. 70% protein).
Placentas from the 70% protein group had significantly more small placentomes, but significantly fewer large placentomes compared to the 70% global group. However, there were no significant differences between the three dietary groups for either the aortic or the umbilical Doppler velocimetry parameters and the fetal heart rate or heart size.
The present study shows that early mild maternal undernutrition produces subtle changes in cotelydonary weight. However, Doppler and echocardiographic parameters were not affected by these changes.
我们想要研究妊娠早期的实验性饮食调控是否会影响胎盘生长，以及随后通过超声对绵羊胎儿进行无创评估时对心血管系统产生影响。
将21只怀有单胎且年龄一致的母羊在妊娠前半期随机分配到以下研究组之一：给予其100%的营养需求（即对照组）、总体摄入量全球减少30%（即全球70%）以及蛋白质摄入量减少30%（即蛋白质70%）。
与全球70%组相比，蛋白质70%组的胎盘有显著更多的小胎盘小叶，但大胎盘小叶显著更少。然而，三个饮食组在主动脉或脐动脉多普勒测速参数、胎儿心率或心脏大小方面均无显著差异。
本研究表明，妊娠早期母亲轻度营养不良会使胎盘叶重量产生细微变化。然而，这些变化并未影响多普勒和超声心动图参数。
