Rosas Peralta M
Servicio de Cardiología Adultos, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, 14080 México, D.F.
Arch Cardiol Mex. 2001 Jan-Mar;71 Suppl 1:S153-9.
A fundamental structural event in the progression of heart failure is myocardial remodeling. New mechanisms have been identified to be related with the cellular and molecular process of remodeling. The interaction between the multiple intracellular and extracellular signaling pathways have been recognized to be crucial for understanding the mechanisms that lead to the transition between cardiac hypertrophy and heart failure. Thus, the goal of this review is to summarize recent findings regarding the molecular and cellular mechanisms involved in the failing heart. The role of apoptosis, extracellular matrix, biochemical and molecular changes, signaling pathways, cytokines, inflammatory response and gene expression are discussed as well as the new possible alternatives for therapy.
心力衰竭进展过程中的一个基本结构事件是心肌重塑。已确定新的机制与重塑的细胞和分子过程相关。多种细胞内和细胞外信号通路之间的相互作用被认为对于理解导致心脏肥大和心力衰竭之间转变的机制至关重要。因此，本综述的目的是总结关于衰竭心脏中涉及的分子和细胞机制的最新发现。还讨论了细胞凋亡、细胞外基质、生化和分子变化、信号通路、细胞因子、炎症反应和基因表达的作用以及新的可能治疗选择。
