Möhlenkamp S, Behrenbeck T R, Lerman A, Lerman L O, Pankratz V S, Sheedy P F, Weaver A L, Ritman E L
Department of Physiology, Mayo Clinic and Foundation, 200 First St SW, Alfred 2-409, Rochester, MN 55905, USA.
Radiology. 2001 Oct;221(1):229-36. doi: 10.1148/radiol.2211001004.
To evaluate the ability of electron-beam computed tomography (CT) to help quantify long-term changes in coronary microvascular functional reserve in a porcine model.
Electron-beam CT-based intramyocardial blood volume and perfusion and Doppler ultrasonography (US)-based intracoronary blood flow were obtained in 13 pigs at baseline and again 3 months later. Measurements were obtained at rest and after the administration of adenosine. The short-term variation during 30 minutes of electron-beam CT measurements was assessed in nine additional pigs.
Short-term variation of blood volume and perfusion averaged 8% and 9%, respectively, and was similar for both weight groups at rest and after adenosine administration. At rest, intracoronary blood flow, blood volume, and perfusion remained unchanged from baseline to follow-up. Long-term increases (percentage change with adenosine relative to that at rest) in blood volume and perfusion reserves were consistent with increasing intracoronary blood flow reserves. Despite these long-term changes in intracoronary blood flow, blood volume, and perfusion, the blood volume-to-perfusion relationship suggests a similar blood volume distribution among different microvascular functional components in normal porcine myocardium at both weight groups.
Electron-beam CT may be of value for quantifying long-term changes in intramyocardial microvascular function.
评估电子束计算机断层扫描（CT）在猪模型中帮助量化冠状动脉微血管功能储备长期变化的能力。
对13头猪在基线时以及3个月后再次进行基于电子束CT的心肌内血容量和灌注测量，以及基于多普勒超声（US）的冠状动脉内血流测量。在静息状态和给予腺苷后进行测量。另外对9头猪评估电子束CT测量30分钟内的短期变化。
血容量和灌注的短期变化平均分别为8%和9%，在静息状态和给予腺苷后，两个体重组的变化相似。静息时，从基线到随访，冠状动脉内血流、血容量和灌注均无变化。血容量和灌注储备的长期增加（腺苷激发后相对于静息时的百分比变化）与冠状动脉内血流储备增加一致。尽管冠状动脉内血流、血容量和灌注有这些长期变化，但血容量与灌注的关系表明，两个体重组正常猪心肌不同微血管功能成分之间的血容量分布相似。
电子束CT可能有助于量化心肌内微血管功能的长期变化。
