Pak M W, To K F, Leung S F, van Hasselt C A
Division of Otorhinolaryngology, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, SAR China.
Laryngoscope. 2001 Aug;111(8):1453-8. doi: 10.1097/00005537-200108000-00023.
To evaluate the potential use of contact endoscopy for the diagnosis of nasopharyngeal carcinoma (NPC).
Prospective study to examine the nasopharynx of 30 patients with nasopharyngeal carcinoma and 18 subjects with normal nasopharynx in a clinic setting using contact rhinoscopes (Karl Storz, Tuttlingen, Germany, 7215 AA, 00 and 7215 BA, 300; 23 cm long; 4 mm in diameter).
The superficial cells of the normal nasopharynx and the nasopharyngeal tumors were stained with 1% methylene blue and examined with contact rhinoscopes at high magnifications (x 60 and x 150). The areas under examination were then biopsied. The contact endoscopic images were compared with the corresponding hematoxylin and eosin-stained histologic sections of the biopsied tissues.
Sixty-six procedures were performed in 48 patients. The images of normal pseudostratified ciliated epithelium and squamous epithelium were readily recognized by contact endoscopy in all subjects with normal nasopharynx (10 men and 8 women; mean age, 51.9 y). Twenty-six of 30 patients with NPC (86.6%; 18 men and 8 women; mean age, 50.6 y) were successfully examined by contact endoscopy under local anesthesia. In these 26 patients, two patterns of malignant cells were identified with contact endoscopy. The patterns of contact endoscopic images corresponded well with the histologic findings.
Contact endoscopy is an accurate and reliable office-based procedure, which allows for in-vivo diagnosis of nasopharyngeal carcinoma.
评估接触式内镜在鼻咽癌（NPC）诊断中的潜在应用价值。
一项前瞻性研究，在临床环境中使用接触式鼻内镜（德国图特林根卡尔·史托斯公司，型号7215 AA，00和7215 BA，300；长23厘米；直径4毫米）对30例鼻咽癌患者和18例鼻咽正常受试者的鼻咽部进行检查。
用1%亚甲蓝对正常鼻咽部和鼻咽肿瘤的表层细胞进行染色，然后使用接触式鼻内镜在高倍镜（×60和×150）下检查。随后对检查部位进行活检。将接触式内镜图像与活检组织相应的苏木精-伊红染色组织学切片进行比较。
48例患者共进行了66次操作。在所有鼻咽正常的受试者（10名男性和8名女性；平均年龄51.9岁）中，通过接触式内镜很容易识别出正常假复层纤毛上皮和鳞状上皮的图像。30例NPC患者中有26例（86.6%；18名男性和8名女性；平均年龄50.6岁）在局部麻醉下通过接触式内镜成功检查。在这26例患者中，通过接触式内镜识别出两种恶性细胞模式。接触式内镜图像模式与组织学结果非常吻合。
接触式内镜是一种准确可靠的门诊检查方法，可用于鼻咽癌的活体诊断。
