Division of Head and Neck Oncology and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Victoria Hospital, University of Western Ontario, London, Ontario, Canada N6A 5W9.
J Oncol. 2011;2011:196302. doi: 10.1155/2011/196302. Epub 2010 Dec 16.
Background. There are a variety of described noninvasive optical detection techniques for evaluation of head and neck mucosal lesions. Contact endoscopy is a promising method of in vivo microscopic examination whereby a rigid telescope is placed on a previously dye-stained mucosa allowing evaluation of the superficial cell layers of the epithelium. This technique produces real-time, magnified images of cellular architecture of surface mucosa comparable to histology without the need for biopsy. In this review, we will briefly summarize the efficacy of CE in the detection of precancerous and cancerous mucosal lesions and its potential as a novel technique in early diagnosis, monitoring, and preoperative assessment of mucosal lesions of the head and neck. Methods. PUBMED, MEDLINE, and COCHRANE search revealed five prospective articles on contact endoscopy for the diagnosis of mucosal lesions in the head and neck. Results. The literature search yielded five prospective studies examining contact endoscopy for the diagnosis of benign versus malignant head and neck mucosal lesions. These reported a sensitivity and specificity of 77-100%, specificity of 66-100% and an accuracy of 72-92%. Conclusion. Contact endoscopy is a promising optical technology that may be a useful adjunct in the evaluation and diagnosis of benign and malignant head and neck mucosal lesions. Future prospective randomized double-blind studies of this detection method are required.
有多种描述的非侵入性光学检测技术可用于评估头颈部黏膜病变。接触式内镜检查是一种有前途的活体显微镜检查方法，通过该方法，刚性望远镜放置在先前染色的黏膜上，可评估上皮的浅层细胞层。该技术可实时放大表面黏膜的细胞结构图像，与组织学相似，但无需活检。在这篇综述中，我们将简要总结 CE 在检测癌前和癌性黏膜病变中的作用，以及其作为一种新的早期诊断、监测和术前评估头颈部黏膜病变的技术的潜力。
PUBMED、MEDLINE 和 COCHRANE 搜索显示了五篇关于接触式内镜检查用于诊断头颈部黏膜病变的前瞻性文章。
文献搜索结果显示，五篇前瞻性研究检查了接触式内镜检查对良性和恶性头颈部黏膜病变的诊断。这些研究报告了 77-100%的敏感性和特异性、66-100%的特异性和 72-92%的准确性。
接触式内镜检查是一种很有前途的光学技术，可能是评估和诊断良性和恶性头颈部黏膜病变的有用辅助手段。需要进行这项检测方法的未来前瞻性随机双盲研究。
