Hoistad D L, Melnik G, Mamikoglu B, Battista R, O'Connor C A, Wiet R J
Department of Otolaryngology-Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA.
Otol Neurotol. 2001 Sep;22(5):682-5. doi: 10.1097/00129492-200109000-00021.
To update the authors' experience with conservative management of acoustic neuromas.
Retrospective chart review.
Private practice and tertiary care referral setting.
Of 600 patients with acoustic neuroma, 102 were treated with the "wait and scan" treatment option. At least two magnetic resonance imaging scans were required of all patients.
Change in tumor size over time was evaluated, as were clinical symptoms: hearing status, tinnitus, balance disturbance, aural fullness, vertigo, headache, and facial pain, numbness, or weakness.
Of 102 patients, the average follow-up time interval was 28.5 months. Forty-five (44%) of 102 patients demonstrated a change in tumor size: an average total growth of 2.17 mm per year. In the remaining 54 patients (53%), no growth was demonstrated during a mean follow-up of 28.5 months. Three patients demonstrated actual tumor shrinkage. Of the 102 patients receiving conservative treatment, 85 (84%) reported hearing loss, 67 (66%) tinnitus, 37 (36%) balance disturbance, 29 (28%) aural fullness, 28 (27%) vertigo, 7 (7%) headache, 4 (4%) facial numbness, 2 (2%) facial weakness, and 0 (0%) facial pain.
Conservative management-"wait and scan"-for selected patients with acoustic neuroma is a reasonable choice of management instead of radiation or microsurgery. In some situations the individual morbidities associated with surgery or radiation make those treatments not in the patient's best interests. A third option is necessary in patients who cannot or do not wish to undergo those other treatments.
更新作者对听神经瘤保守治疗的经验。
回顾性病历审查。
私人诊所和三级医疗转诊机构。
在600例听神经瘤患者中,102例采用“观察与扫描”治疗方案。所有患者均至少需要进行两次磁共振成像扫描。
评估肿瘤大小随时间的变化以及临床症状,包括听力状况、耳鸣、平衡障碍、耳闷、眩晕、头痛以及面部疼痛、麻木或无力。
102例患者的平均随访时间为28.5个月。102例患者中有45例(44%)肿瘤大小发生变化,平均每年总体生长2.17毫米。其余54例患者(53%)在平均28.5个月的随访期间未出现生长。3例患者肿瘤实际缩小。在接受保守治疗的102例患者中,85例(84%)报告有听力损失,67例(66%)有耳鸣,37例(36%)有平衡障碍,29例(28%)有耳闷,28例(27%)有眩晕,7例(7%)有头痛,4例(4%)有面部麻木,2例(2%)有面部无力,0例(0%)有面部疼痛。
对于部分听神经瘤患者,保守治疗——“观察与扫描”——是一种合理的治疗选择,可替代放疗或显微手术。在某些情况下,与手术或放疗相关的个体发病率使这些治疗不符合患者的最大利益。对于无法或不愿接受其他治疗的患者,需要第三种选择。