Porter T R, Xie F
Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198-1165, USA.
Prog Cardiovasc Dis. 2001 Sep-Oct;44(2):101-10. doi: 10.1053/pcad.2001.26441.
Although dissolution of thrombus using ultrasound has been attempted for over 25 years, the clinical use of this technique remains limited. The ability of microbubbles to potentiate ultrasound-induced thrombolysis has renewed interest in this technique, which recanalizes occluded vessels without the need for fibrinolytic therapy. In this article, the potential mechanisms by which ultrasound and microbubbles produce thrombus dissolution are explored. In vitro and in vivo studies using ultrasound alone and ultrasound in combination with microbubbles to cause thrombolysis are reviewed. Potential clinical implications of more recent findings are explored.
尽管利用超声溶解血栓的尝试已有25年以上，但这项技术的临床应用仍然有限。微泡增强超声诱导溶栓的能力重新引发了人们对该技术的兴趣，该技术可使闭塞血管再通，而无需进行纤维蛋白溶解疗法。在本文中，探讨了超声和微泡产生血栓溶解的潜在机制。综述了单独使用超声以及超声与微泡联合使用进行溶栓的体外和体内研究。探讨了最新研究结果的潜在临床意义。
