Burmistrova A L, Isakanova A O, Prazdnov A S, Suslova T A
State University, Medical Academy, Regional Blood Transfusion Station, Chelyabinsk, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2001 Jul-Aug(4):117-9.
The immune status and profile of HLA antigens of loci A and B were evaluated in 159 patients with reactive arthritis. Reactive arthritis was caused by urogenital chlamydial infection in 64.2% of cases and by Shigella, Salmonella and Yersinia enterocolitica infection in 18.9% of cases. In patients with different etiology of the disease some variations in its course and outcome, immune status as well as in the HLA antigen profile were established that is indicative of genetic determination of the immune response character. The established specific variations in the immune and immunogenetic status of patients with reactive arthritis of different etiology may be used for improving diagnosis and treatment efficacy.
对159例反应性关节炎患者的免疫状态以及HLA-A和HLA-B位点抗原谱进行了评估。64.2%的反应性关节炎病例由泌尿生殖系统衣原体感染引起，18.9%的病例由志贺氏菌、沙门氏菌和小肠结肠炎耶尔森氏菌感染引起。在疾病病因不同的患者中，其病程和转归、免疫状态以及HLA抗原谱存在一些差异，这表明免疫反应特征具有遗传决定性。不同病因的反应性关节炎患者免疫和免疫遗传学状态所确定的特定差异可用于提高诊断和治疗效果。
