Bugorkova S A, Isupov I V, Nazarova L S, Eliseev Iu Iu
Research Institute for Plague Control Microbe, Saratov, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 2001 Jul-Aug(4):27-31.
The morphofunctional state of apudocytes in the gastrointestinal tract and immunocompetent organs (spleen, mesenteric lymph nodes) of mice immunized with chemical bivalent cholera vaccine was studied. The study revealed that the APUD system of the intestine and the argyrophil elements of the immunocompetent organs of white mice gave a response to the oral administration of commercial cholera vaccine. The reaction of the APUD system of the gastrointestinal tract was manifested by a significant increase in the number of apudocytes and their greater synthesizing activity in the immunized animals during the period of maximum immunological transformation of the macroorganism. The immunization of mice with Vibrio cholerae facilitated the maintenance of homeostasis in the macroorganism and prevented appearance of morphological disturbances in its organs and system after subsequent challenge with V. cholerae.
研究了用化学二价霍乱疫苗免疫的小鼠胃肠道及免疫活性器官（脾脏、肠系膜淋巴结）中APUD细胞的形态功能状态。研究发现，小白鼠肠道的APUD系统及免疫活性器官的嗜银成分对口服市售霍乱疫苗有反应。在机体发生最大免疫转化期间，免疫动物胃肠道APUD系统的反应表现为APUD细胞数量显著增加及其合成活性增强。用霍乱弧菌免疫小鼠有助于维持机体的稳态，并防止在随后用霍乱弧菌攻击后其器官和系统出现形态学紊乱。
