组氨酸对5-羟色胺1A受体激动剂8-羟基-二丙基氨基四氢萘诱导的工作记忆缺陷的影响。

Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT.

作者信息

Isayama S, Sugimoto Y, Nishiga M, Kamei C

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

出版信息

Jpn J Pharmacol. 2001 Aug;86(4):451-3. doi: 10.1254/jjp.86.451.

DOI:10.1254/jjp.86.451

PMID:11569620

Abstract

We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

摘要

我们研究了组氨酸对5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）诱导的空间记忆缺陷的影响。8-OH-DPAT引发了工作记忆缺陷，但不影响参考记忆。组氨酸在导致脑组胺含量显著增加的剂量下改善了8-OH-DPAT诱导的工作记忆缺陷。这一发现表明组胺能系统调节8-OH-DPAT诱导的工作记忆缺陷。