Saha R N, Sajeev C, Sahoo J
Pharmacy Group, Birla Institute of Technology & Science, Pilani, India.
Drug Deliv. 2001 Jul-Aug;8(3):149-54. doi: 10.1080/107175401316906919.
The need for controlled release formulations for diclofenac sodium, ciprofloxacin, and theophylline is well recognized. In our study, controlled release tablets of the three drugs were formulated by the matrix-embedding technique using ethyl cellulose as retardant. Tablets of all the drugs were of good physical quality with respect to appearance, drug content uniformity, hardness, weight variation, and friability. In vitro release rate studies showed that ethyl cellulose extended the release of the three drugs to 12 hr or more. Release patterns from formulations of the three drugs followed Higuchi's square root kinetics. At pH 6.8, the release rate was higher in all three drugs, probably due to increased solubility of the drugs and/or increased swelling of ethyl cellulose at the higher pH. The formulations were highly stable and possessed reproducible release kinetics across batches.
双氯芬酸钠、环丙沙星和茶碱的控释制剂的需求已得到广泛认可。在我们的研究中，采用乙基纤维素作为阻滞剂，通过基质包埋技术制备了这三种药物的控释片。所有药物片剂在外观、药物含量均匀性、硬度、重量差异和脆碎度方面均具有良好的物理质量。体外释放速率研究表明，乙基纤维素将三种药物的释放延长至12小时或更长时间。三种药物制剂的释放模式遵循Higuchi平方根动力学。在pH 6.8时，所有三种药物的释放速率均较高，这可能是由于药物溶解度增加和/或在较高pH下乙基纤维素溶胀增加所致。这些制剂高度稳定，并且批次间具有可重现的释放动力学。
