Repka-Ramirez M S, Naranch K, Park Y J, Velarde A, Clauw D, Baraniuk J N
Department of Medicine, Georgetown University, Washington, DC 20007-2197, USA.
Ann Allergy Asthma Immunol. 2001 Sep;87(3):218-21. doi: 10.1016/S1081-1206(10)62229-6.
Chronic fatigue syndrome (CFS) has an uncertain pathogenesis. Allergies have been suggested as one cause.
The aim of this study was to compare serum immunoglobulin (Ig)E in CFS and control subjects to determine whether IgE levels were elevated in CFS. This would be suggestive of increased atopy in CFS.
IgE was measured by quantitative ELISA (sandwich) immunoassay in 95 CFS and 109 non-CFS control subjects. Subjects were classified by positive or negative allergy skin tests (AST) and rhinitis questionnaires (rhinitis score, RhSc) into four rhinitis types: nonallergic rhinitis (NAR with positive RhSc and negative AST); allergic rhinitis (AR with positive AST and RhSc); atopic/no rhinitis (AST positive/RhSc negative); and nonatopic/no rhinitis (both AST and RhSc negative) subjects.
IgE was not significantly different between control (128 +/- 18 IU/mL, mean +/- SEM) and CFS (133 +/- 43 IU/mL) groups, or between control and CFS groups classified into the four rhinitis types. IgE was significantly higher in subjects with positive AST whether or not they had positive RhSc or CFS symptoms.
Elevated IgE and positive AST indicate allergen sensitization, but are not necessarily indicators of symptomatic allergic diseases. There was no association between IgE levels and CFS, indicating that atopy was probably not more prevalent in CFS. Therefore, TH2-lymphocyte and IgE-mast cell mechanisms are unlikely causes of CFS.
慢性疲劳综合征（CFS）的发病机制尚不确定。有观点认为过敏是其病因之一。
本研究旨在比较CFS患者与对照受试者的血清免疫球蛋白（Ig）E水平，以确定CFS患者的IgE水平是否升高。这可能提示CFS患者的特应性增加。
采用定量ELISA（夹心）免疫分析法检测95例CFS患者和109例非CFS对照受试者的IgE。通过过敏皮肤试验（AST）和鼻炎问卷（鼻炎评分，RhSc）将受试者分为四类鼻炎类型：非过敏性鼻炎（RhSc阳性且AST阴性的NAR）；过敏性鼻炎（AST和RhSc均阳性的AR）；特应性/无鼻炎（AST阳性/RhSc阴性）；非特应性/无鼻炎（AST和RhSc均阴性）受试者。
对照组（128±18 IU/mL，均值±标准误）和CFS组（133±43 IU/mL）之间，以及分为四类鼻炎类型的对照组和CFS组之间，IgE无显著差异。无论RhSc是否阳性或有无CFS症状，AST阳性的受试者IgE均显著更高。
IgE升高和AST阳性表明过敏原致敏，但不一定是症状性过敏性疾病的指标。IgE水平与CFS之间无关联，表明特应性在CFS中可能并不更普遍。因此，TH2淋巴细胞和IgE-肥大细胞机制不太可能是CFS的病因。
