Ahuja T S, Boughton J, Weiss V, Memon A, Remmers A, Rajaraman S
Department of Medicine, University of Texas Medical Branch Galveston, USA.
Am J Med Sci. 2001 Sep;322(3):166-9. doi: 10.1097/00000441-200109000-00012.
Clinically significant recurrence of lupus nephritis in the renal allograft is low, with an incidence of 1 to 3%, and usually occurs within the first 6 years after transplantation. We report an unusual case of a patient with end-stage renal disease caused by lupus nephritis who received a kidney transplant from a living relative; 13 years later, the patient had a severe recurrence of diffuse proliferative lupus nephritis. The patient relapsed after receiving intravenous cyclophosphamide therapy and had a partial response to oral mycophenolate mofetil. In this report we review the risk factors for the recurrence of the systemic lupus erythematosus in the kidney graft and the anti-lupus activity of mycophenolate mofetil.
肾移植中狼疮性肾炎具有临床意义的复发率较低，为1%至3%，且通常发生在移植后的头6年内。我们报告了一例不同寻常的病例，一名因狼疮性肾炎导致终末期肾病的患者接受了来自活体亲属的肾移植；13年后，该患者出现弥漫性增殖性狼疮性肾炎的严重复发。患者在接受静脉注射环磷酰胺治疗后复发，对口服霉酚酸酯有部分反应。在本报告中，我们回顾了肾移植中系统性红斑狼疮复发的危险因素以及霉酚酸酯的抗狼疮活性。
