采用气液色谱法测定全血中的氯硝西泮。
The measurement of Rivotril in whole blood by gas liquid chromatography.
作者信息
Shapcott D, Lemieux B
出版信息
Clin Biochem. 1975 Aug;8(4):283-7. doi: 10.1016/s0009-9120(75)92948-3.
PMID:1157296
Abstract
Rivotril is extracted from blood into an organic solvent mixture, Mogadon, (Nitrazepam) is used as internal standard. The drugs are then back-extracted into acid which is heated to produce the corresponding benzophenones. These are extracted into benzene and separated by gas liquid chromatography with electron capture detection.
摘要
氯硝西泮从血液中萃取到一种有机溶剂混合物中，以硝西泮作为内标。然后将药物反萃取到酸中，加热酸以生成相应的二苯甲酮。将这些二苯甲酮萃取到苯中，并用电子捕获检测的气相色谱法进行分离。
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