对映选择性钌催化的闭环复分解反应。

Enantioselective ruthenium-catalyzed ring-closing metathesis.

作者信息

Seiders T J, Ward D W, Grubbs R H

机构信息

Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

出版信息

Org Lett. 2001 Oct 4;3(20):3225-8. doi: 10.1021/ol0165692.

DOI:10.1021/ol0165692

PMID:11574037

Abstract

[reaction: see text] The first enantioselective ruthenium olefin metathesis catalysts have been prepared, and high enantiomeric excesses (up to 90%) are observed in the desymmetrization of achiral trienes. A model consistent with the stereochemical outcome of the reactions is described and suggests side-on olefin binding and reorganization of the halide ligands.

摘要

[反应：见正文] 已制备出首例对映选择性钌烯烃复分解催化剂，在手性三烯的去对称化反应中观察到了高对映体过量（高达90%）。描述了一个与反应立体化学结果相符的模型，该模型表明烯烃为侧基配位以及卤化物配体的重排。