接受化疗的卵巢癌患者的血清促红细胞生成素水平
Serum erythropoietin levels in ovarian cancer patients receiving chemotherapy.
作者信息
Pedain C, Herrero J, Künzel W
机构信息
Department of Obstetrics and Gynaecology, University of Giessen, Klinikstrasse 32, 35392 Giessen, Germany.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2001 Oct;98(2):224-30. doi: 10.1016/s0301-2115(01)00336-0.
OBJECTIVE
To investigate the effects of repeated cis-dichlorodiamine-platinum (CDDP) exposure on serum erythropoietin (Epo) levels.
STUDY DESIGN
In seven patients with ovarian cancer, Epo and haemoglobin concentration (c(Hb)) were measured before, 24h and 7 days after administration of the first three courses of chemotherapy. In seven control patients undergoing gynaecological surgery for non-malignant reasons, Epo and c(Hb) were measured before, 24h and 7 days after the operation.
RESULTS
Following Epo increased, independent of concomitant anaemia, especially after the third course: 51mU/ml (S.D. 46) versus 122mU/ml (S.D. 83) (P=0.02). In the control patients, Epo was lower although the decrease of c(Hb) was significantly higher.
CONCLUSION
Cis-platinum chemotherapy induces an increase in erythropoietin levels independent of anaemia. The underlying mechanism remains to be investigated.
目的
研究重复暴露于顺式二氯二氨铂（CDDP）对血清促红细胞生成素（Epo）水平的影响。
研究设计
对7例卵巢癌患者，在给予前三疗程化疗前、化疗后24小时及7天时测量Epo和血红蛋白浓度（c(Hb)）。对7例因非恶性原因接受妇科手术的对照患者，在手术前、术后24小时及7天时测量Epo和c(Hb)。
结果
Epo升高，与同时存在的贫血无关，尤其是在第三疗程后：51mU/ml（标准差46）对122mU/ml（标准差83）（P=0.02）。在对照患者中，尽管c(Hb)下降幅度明显更大，但Epo较低。
结论
顺铂化疗可导致促红细胞生成素水平升高，与贫血无关。其潜在机制仍有待研究。
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