Mandel W J, Laks M M, Obayashi K
Chest. 1975 Sep;68(3):321-5. doi: 10.1378/chest.68.3.321.
Wolff, Parkinson, and White, in their initial description of the syndrome that bears their names, emphasized the association of tachycardias with the electrocardiographic abnormality. Subsequent investigations have identified, both anatomically and electrophysiologically, that dual pathways of atrioventricular (AV) conduction exist. Furthermore, experimental and clinical evidence has stressed that the mechanism of tachycardia production in the syndrome appears to reentry utilizing these dual pathways. However, recent studies have emphasized that other mechanisms of tachycardia production may be responsible for the arrhythmias seen in this syndrome. The present report identifies that AV nodal reentry may be the sole mechanism for tachycardia induction in the Wolff-Parkinson-White (WPW) syndrome. This finding may be of great clinical significance in light of the availability of surgical therapy for WPW patients with intractable arrhythmias.
沃尔夫、帕金森和怀特在首次描述以他们名字命名的综合征时，强调了心动过速与心电图异常之间的关联。随后的研究在解剖学和电生理学方面都证实，存在房室（AV）传导的双径路。此外，实验和临床证据都强调，该综合征中心动过速的产生机制似乎是利用这些双径路进行折返。然而，最近的研究强调，其他心动过速产生机制可能是该综合征中所见心律失常的原因。本报告指出，房室结折返可能是预激综合征（WPW）中诱发心动过速的唯一机制。鉴于对于患有顽固性心律失常的WPW患者可采用手术治疗，这一发现可能具有重大的临床意义。
