HIV-1核苷类逆转录酶抑制剂耐药机制：都弄清楚了吗？
Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out?
作者信息
Naeger L K, Miller M D
机构信息
Gilead Sciences Inc, Foster City, CA 94404, USA.
出版信息
Curr Opin Investig Drugs. 2001 Mar;2(3):335-9.
PMID:11575701
Abstract
The mechanistic basis for some examples of HIV-1 NRTI-resistance can be examined using altered incorporation of nucleoside analogs and surveying what is known about the more recently described mechanisms of chain-terminator removal. The complexity of these resistance mechanisms and the interplay with other factors that contribute to NRT1 resistance are only just beginning to be appreciated.
摘要
可以通过改变核苷类似物的掺入情况以及探究有关最近描述的链终止剂去除机制的已知信息，来研究HIV-1核苷类逆转录酶抑制剂耐药性某些实例的机制基础。这些耐药机制的复杂性以及与导致核苷类逆转录酶抑制剂耐药性的其他因素之间的相互作用，才刚刚开始被认识到。
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