Nogawa T, Kamano Y, Yamashita A, Pettit G R
Faculty of Science, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan.
J Nat Prod. 2001 Sep;64(9):1148-52. doi: 10.1021/np0101088.
Five new bufadienolides, 3beta-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6alpha-hydroxycinobufagin (4), and 1beta-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.
从中国传统药物“蟾酥”中分离出了5种新的蟾蜍二烯羟酸内酯，即3β-甲酰氧基脂蟾毒配基（1）、19-氧代蟾毒灵（2）、19-氧代去乙酰华蟾毒精（3）、6α-羟基华蟾毒精（4）和1β-羟基蟾毒灵（5），同时还分离出了之前已知的蟾蜍二烯羟酸内酯6 - 20。通过光谱方法阐明了这些化合物的结构。蟾蜍二烯羟酸内酯1 - 5对KB和HL - 60癌细胞系具有显著的抑制活性。此外，还发现蟾蜍二烯羟酸内酯1对MH - 60癌细胞系有活性。
