Ng H.T., Shyu S.K., Chen Y.K., Yuan C.C., Chao K.C., Kan Y.Y.
Department of Obstetrics and Gynecology, and Department of Pathology, National Yang-Ming Medical College; Veterans General Hospital, Taipei, Taiwan, ROC.
Int J Gynecol Cancer. 1992 Mar;2(2):75-78. doi: 10.1046/j.1525-1438.1992.02020075.x.
An evaluation was made of factors that affect the recurrence of cervical cancer after primary surgery, these including age, clinical stage, histology, grade, involvement of uterine body, parametrium or vagina and lymph node metastases. During a period of at least 3 years, 702 of 1508 patients who underwent radical hysterectomy and pelvic lymph node dissection were studied by using a scoring system. A comparison between the group of women scored at or greater than 13 that scored less than 13 revealed that the risk of recurrence was higher in the former group. One hundred and twenty five of 702 patients found to have positive pelvic node involvement scored greater than 13, which rendered them eligible for further mangement as follows: the recurrence rate in 99 patients receiving multi-agent chemotherapy was 34.4%, compared with 65.4% in 26 patients receiving no treatment (P < 0.01). Applying this score to other patients in planning adjuvant therapy, the recurrence rate may be reduced further. The number of patients needlessly exposed to the toxic effects of multi-agent chemotherapy may be reduced also.
对影响宫颈癌初次手术后复发的因素进行了评估，这些因素包括年龄、临床分期、组织学、分级、子宫体、宫旁组织或阴道受累情况以及淋巴结转移。在至少3年的时间里，对1508例行根治性子宫切除术和盆腔淋巴结清扫术的患者中的702例使用评分系统进行了研究。对评分在13分及以上的女性组和评分低于13分的女性组进行比较，结果显示，前一组的复发风险更高。702例被发现盆腔淋巴结受累阳性的患者中，125例评分大于13分，这使他们有资格接受如下进一步治疗：99例接受多药化疗的患者复发率为34.4%，而26例未接受治疗的患者复发率为65.4%（P<0.01）。在规划辅助治疗时将该评分应用于其他患者，复发率可能会进一步降低。不必要地暴露于多药化疗毒性作用的患者数量也可能会减少。
