左氧氟沙星在自发性急性细菌性脑膜炎患者中的脑脊液穿透情况。
Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis.
作者信息
Scotton P G, Pea F, Giobbia M, Baraldo M, Vaglia A, Furlanut M
机构信息
Department of Infectious Diseases, Regional Hospital Cà Foncello, Treviso, Italy.
出版信息
Clin Infect Dis. 2001 Nov 1;33(9):e109-11. doi: 10.1086/323406. Epub 2001 Sep 26.
DOI:10.1086/323406
PMID:11577376
Abstract
We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99+/-0.67 microg/mL, and the C(L)/C(P) at 2 hours after dosing was 0.34+/-0.09.
摘要
我们评估了5例自发性急性细菌性脑膜炎患者给药2小时后脑脊液（CSF）中左氧氟沙星的渗透率以及脑脊液与血浆浓度比（C(L)/C(P)）。给药2小时后的脑脊液左氧氟沙星浓度为1.99±0.67微克/毫升，给药2小时后的C(L)/C(P)为0.34±0.09。
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