de Simone G, Devereux R B, Kimball T R, Roman M J, Palmieri V, Celentano A, Daniels S R
Division of Cardiology, Weill Medical College of Cornell University, New York, NY, USA.
Ital Heart J. 2001 Aug;2(8):599-604.
The quantitative relation between body growth and changes in heart rate, and the relationship of heart rate to left ventricular (LV) dimensions, independent of the influence of body size, have been only marginally investigated. Accordingly, we designed this study to investigate the relation between heart rate, body size and LV dimensions in children, adolescents and adults over a broad age span.
Eight hundred and nineteen normotensive, multi-racial, normal-weight individuals (444 males, 375 females, aged 1-85 years) with normal LV systolic function were studied at echocardiography in three centers, using previously reported methods. The resting heart rate was measured on the M-mode echo-tracing or right after the echocardiogram with the subject still in the supine position.
In children and adolescents (up to 17 years), the heart rate decreased with increasing body height (r = -0.51, p < 0.0001) and body weight (r = -0.42, p < 0.0001), in a similar manner in girls and boys. In adults, the heart rate was higher in women than in men, but it was not independently related to body size. The LV diastolic diameter was higher in males and decreased with increasing heart rate in children and adolescents (r = -0.45) as well as in adults (r = -0.25, both p < 0.0001). This relation was also independent of the effect of body size, sex and race. Similarly, the LV mass increased with decreasing heart rate in children and adolescents (r = -0.45), but the association was not confirmed after controlling for body size, sex and race. In adults, heart rate was inversely related to LV mass (r = -0.21, p < 0.0001), and this relation was also independent of body size, sex, race, age and blood pressure (p < 0.001). In women, the relation of heart rate to LV mass/height2.7 was less close than in men, due to the greater increase in LV mass with age.
The heart rate has an inverse association with the LV chamber diameter and with the LV mass in children-adolescents and in adults. This relation is largely, but not uniquely, mediated by body proportions, especially during body growth.
身体生长与心率变化之间的定量关系，以及心率与左心室（LV）尺寸之间的关系（独立于身体大小的影响）仅得到了少量研究。因此，我们设计了这项研究，以调查广泛年龄范围内儿童、青少年和成人的心率、身体大小与左心室尺寸之间的关系。
在三个中心，使用先前报道的方法，对819名血压正常、多种族、体重正常且左心室收缩功能正常的个体（444名男性，375名女性，年龄1 - 85岁）进行了超声心动图检查。静息心率在M型超声心动图记录时或超声心动图检查刚结束后测量，此时受试者仍处于仰卧位。
在儿童和青少年（17岁及以下）中，心率随着身高（r = -0.51，p < 0.0001）和体重（r = -0.42，p < 0.0001）的增加而降低，男孩和女孩的情况相似。在成年人中，女性的心率高于男性，但心率与身体大小无独立相关性。男性的左心室舒张直径更大，在儿童、青少年（r = -0.45）和成年人（r = -0.25，均p < 0.0001）中，左心室舒张直径均随着心率的增加而减小。这种关系也独立于身体大小、性别和种族的影响。同样，在儿童和青少年中，左心室质量随着心率的降低而增加（r = -0.45），但在控制身体大小、性别和种族后，这种关联未得到证实。在成年人中，心率与左心室质量呈负相关（r = -0.21，p < 0.0001），且这种关系也独立于身体大小、性别、种族、年龄和血压（p < 0.001）。在女性中，由于左心室质量随年龄增加得更多，心率与左心室质量/身高².⁷的关系不如男性密切。
在儿童 - 青少年和成年人中，心率与左心室腔直径及左心室质量呈负相关。这种关系在很大程度上（但并非唯一）由身体比例介导，尤其是在身体生长期间。
