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苯妥英钠所致牙龈增生：其对药物剂量变化的反应。

Diphenylhydantoin-induced gingival hyperplasia: its response to changes in drug dosage.

作者信息

Little T M, Girgis S S, Masotti R E

出版信息

Dev Med Child Neurol. 1975 Aug;17(4):421-4. doi: 10.1111/j.1469-8749.1975.tb03492.x.

DOI:10.1111/j.1469-8749.1975.tb03492.x
PMID:1158048
Abstract

Changes in gingival hyperplasia were studied in 48 patients treated for epilepsy with diphenylhydantoin (DPH) over a two-year period. During this time changes in the dose of DPH were made in some patients in order to increase control of seizures or decrease side-effects: in 27 patients the dose was increased, in nine it was decreased and in 12 the dose remained unchanged. It was found that the severity of gingival hyperplasia varied directly with both the dose and serum level of the drug.

摘要

对48例接受苯妥英钠（DPH）治疗癫痫的患者进行了为期两年的牙龈增生变化研究。在此期间，部分患者调整了DPH剂量，以增强癫痫控制或减少副作用：27例患者剂量增加，9例患者剂量减少，12例患者剂量保持不变。结果发现，牙龈增生的严重程度与药物剂量和血清水平直接相关。

相似文献

1
Diphenylhydantoin-induced gingival hyperplasia: its response to changes in drug dosage.苯妥英钠所致牙龈增生：其对药物剂量变化的反应。
Dev Med Child Neurol. 1975 Aug;17(4):421-4. doi: 10.1111/j.1469-8749.1975.tb03492.x.
2
Diphenylhydantoin-induced gingival hyperplasia: its relationship to dose and serum level.苯妥英钠所致牙龈增生：其与剂量及血清水平的关系。
Dev Med Child Neurol. 1973 Aug;15(4):483-7. doi: 10.1111/j.1469-8749.1973.tb05070.x.
3
The gingival hyperplasia resulting from diphenylhydantoin in children and adults.儿童和成人中由苯妥英引起的牙龈增生。
Int J Clin Pharmacol Biopharm. 1975 Oct;12(3):369-71.
4
Diphenylhydantoin gingival hyperplasia.
Am J Dis Child. 1969 Mar;117(3):265-70. doi: 10.1001/archpedi.1969.02100030267002.
5
Effect of 5,5-diphenylhydantoin on a gingival hyperplasia development.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1980;23(5):625-89.
6
Phenytoin as a risk factor in gingival hyperplasia.苯妥英钠作为牙龈增生的一个风险因素。
Ther Drug Monit. 1995 Oct;17(5):445-8. doi: 10.1097/00007691-199510000-00002.
7
[Gingival hyperplasia in epileptic patients treated with diphenylhydantoin. Study by light and electron microscopy].
Rev Invest Salud Publica. 1973 Jul-Dec;33(3-4):1-16.
8
Incidence of diphenylhydantoin gingival hyperplasia.
Oral Surg Oral Med Oral Pathol. 1972 Dec;34(6):898-906. doi: 10.1016/0030-4220(72)90228-9.
9
Folate treatment of diphenylhydantoin-induced gingival hyperplasia.叶酸治疗苯妥英钠所致牙龈增生
Scand J Dent Res. 1989 Jun;97(3):222-32. doi: 10.1111/j.1600-0722.1989.tb01606.x.
10
[Clinical study of gingival hyperplasia in epilepsy patient].
Shigaku. 1989 Dec;77(4):1401-7.

引用本文的文献

1
Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children.叶酸补充剂可预防苯妥英钠引起的儿童牙龈增生。
Neurology. 2011 Apr 12;76(15):1338-43. doi: 10.1212/WNL.0b013e3182152844.