Orbach D, Romanelli P, Devinsky O, Doyle W
Department of Neurology, NYU School of Medicine, New York, New York, USA.
Epilepsia. 2001 Sep;42(9):1130-3. doi: 10.1046/j.1528-1157.2001.45300.x.
We studied long-term outcome (range, 28-89 months; mean, 56 months) after multiple subpial transections (MST) for medically refractory epilepsy. Forty-three (79.6%) of 54 patients had a consistent significant reduction in seizure frequency, and 27 (50%) of the 54 were either entirely seizure free or virtually so. However, 10 (18.5%) patients sustained an increase in seizure frequency several years after surgery, after showing initial postoperative improvement. This suggests that late seizure recurrence is a more important problem in cases in which MST has been performed than for pure resections.
我们研究了多软膜下横切术（MST）治疗药物难治性癫痫后的长期疗效（范围为28 - 89个月；平均为56个月）。54例患者中有43例（79.6%）癫痫发作频率持续显著降低，54例中有27例（50%）完全无癫痫发作或几乎无发作。然而，10例（18.5%）患者术后初期有改善，但在术后数年癫痫发作频率却持续增加。这表明，与单纯切除手术相比，MST治疗的病例中晚期癫痫复发是一个更重要的问题。
