Yunis E J, Fernandes G, Smith J, Good R A
Transplant Proc. 1976 Dec;8(4):521-5.
(1)Spleen cells from newborn syngeneic and allogeneic mice that lack fully differentiated T lymphocytes can be used as a hematopoietic source to reconstitute both hematopoietic and lymphoid systems of lethally irradiated mice without producing a GVHR. (2) Fetal liver cells from syngeneic and allogeneic mice that lack postthymic T lymphocytes can also be used for hematopoietic and immunologic reconstitution of lethally irradiated mice without producing GVHR. (3) Immunologic deficiency is observed in some experiments in mice given supralethal irradiation (1000 R) and fetal liver as reconstituting hematopoietic tissue. (4) The findings suggest that Tcells, at an early stage of differentiation, are more susceptible to tolerance induction than are T lymphocytes at later stages of differentiation and do not, in general, produce GVHR. (5) It is postulated that hematopoietic cells, free of postthymic lymphoid cells, can be used for hematopoietic or immunologic reconstituting and cellular engineering without producing GVHD.
（1）来自缺乏完全分化T淋巴细胞的新生同基因和异基因小鼠的脾细胞，可作为造血来源，用于重建经致死性照射小鼠的造血和淋巴系统，而不产生移植物抗宿主反应（GVHR）。（2）来自缺乏胸腺后T淋巴细胞的同基因和异基因小鼠的胎肝细胞，也可用于经致死性照射小鼠的造血和免疫重建，而不产生GVHR。（3）在一些实验中，给小鼠进行超致死剂量照射（1000拉德）并将胎肝作为重建造血组织时，观察到免疫缺陷。（4）这些发现表明，分化早期的T细胞比分化后期的T淋巴细胞更容易被诱导产生耐受性，并且一般不会产生GVHR。（5）据推测，不含胸腺后淋巴细胞的造血细胞可用于造血或免疫重建以及细胞工程，而不产生移植物抗宿主病（GVHD）。
