Christensson P I, Rerup C, Seyer-Hansen K, Stenram U
Hoppe Seylers Z Physiol Chem. 1975 May;356(5):591-7. doi: 10.1515/bchm2.1975.356.1.591.
Serum growth hormone was significantly higher in rats fed on a non-protein than on a 25% casein diet. In both dietary groups, hypophysectomy provoked a decrease in the RNA/DNA ratio of the liver, and, especially in the protein-deprived rats, a decrease in the RNA synthesis per liver cell, measured as the product of the RNA/DNA ratio, and the ratio of specific RNA activity to specific nucleotide activity, two hours after administration of [3H]orotic acid. In the protein-deprived rats, full reconstitution of these figures was obtained with a combination of growth hormone, hydrocortisone and triiodothyronine, but not quite with growth hormone alone. The possible role of growth hormone in protein deprivation is discussed.
喂食无蛋白饮食的大鼠血清生长激素水平显著高于喂食25%酪蛋白饮食的大鼠。在两个饮食组中，垂体切除均导致肝脏RNA/DNA比值下降，尤其是在蛋白质缺乏的大鼠中，在给予[3H]乳清酸两小时后，以RNA/DNA比值与特异性RNA活性与特异性核苷酸活性之比的乘积来衡量，每肝细胞的RNA合成减少。在蛋白质缺乏的大鼠中，生长激素、氢化可的松和三碘甲状腺原氨酸联合使用可使这些指标完全恢复，但单独使用生长激素则不能完全恢复。文中讨论了生长激素在蛋白质缺乏中的可能作用。
