Pettinati H M
Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, USA.
J Clin Psychiatry. 2001;62 Suppl 20:26-31.
The usefulness of selective serotonin reuptake inhibitors (SSRIs) to treat alcohol dependence continues to be a subject of debate. Most recently, investigations have tried to predict whether a given patient will respond to SSRIs in terms of reducing excessive alcohol drinking. The subtyping of alcohol-dependent individuals has ranged from relatively simple classifications (e.g., presence of comorbid depression) to more complex classifications (e.g., potential to have abnormalities in serotonin [5-HT] neurotransmission). Although only a few studies have been completed, results thus far indicate that alcoholic subgroups are differentially responsive to 5-HT pharmacotherapy with respect to drinking-related outcomes. In addition, there are preliminary results encouraging the use of SSRIs in combination with other medications for treating alcohol dependence in patients with and without comorbid psychiatric disorders. Information from these studies is promising, suggesting the need for further investigation.
选择性5-羟色胺再摄取抑制剂（SSRIs）用于治疗酒精依赖的有效性仍是一个存在争议的话题。最近，一些研究试图预测特定患者服用SSRIs后在减少过度饮酒方面是否会有反应。对酒精依赖个体的亚型分类范围从相对简单的分类（例如，是否存在共病性抑郁症）到更复杂的分类（例如，5-羟色胺[5-HT]神经传递可能存在异常）。尽管仅完成了少数几项研究，但迄今为止的结果表明，不同酒精依赖亚组在与饮酒相关的结果方面对5-HT药物治疗的反应存在差异。此外，有初步结果支持在患有和未患有共病性精神障碍的患者中使用SSRIs联合其他药物治疗酒精依赖。这些研究的信息很有前景，表明有必要进行进一步调查。
