Tedeschi G G, Amici D
Ital J Biochem. 1975 Mar-Apr;24(2):102-18.
Following the results of previous researches suggesting that platelets might carry microbial forms, the incorporation of 14C-thymidine in suspensions of platelets from 500 normal human subjects has been taken under examination. The results have always yielded positive data even though with marked differences of a quantitative order from a case to another. The hypothesis that such an activity might be the consequence of a synthesis of DNA in the mitochondria had to be excluded. The peculiar relations linking the incorporation rate to the number of platelets and to the presence of plasma or serum in given amounts and the strong inhibition exerted by oxytetracyclines suggest that the detected metabolic activity may be attributed to the presence of bacterial L-forms carried by platelets. The results of cultural, optical and electron microscopical investigations, which will be published elsewere, confirmed such interpretation.
根据先前研究结果表明血小板可能携带微生物形态，对来自500名正常人类受试者的血小板悬液中14C-胸腺嘧啶核苷的掺入情况进行了检测。尽管不同病例之间在数量上存在显著差异，但结果始终呈现阳性数据。必须排除这种活性可能是线粒体中DNA合成结果的假说。掺入率与血小板数量以及给定数量的血浆或血清的存在之间的特殊关系，以及土霉素所产生的强烈抑制作用表明，检测到的代谢活性可能归因于血小板携带的细菌L型的存在。即将在其他地方发表的培养、光学和电子显微镜研究结果证实了这种解释。
