Sayer J A, Pearce S H
Department of Physiological Sciencesy, University of Newcastle upon Tyne, UK.
Ann Clin Biochem. 2001 Sep;38(Pt 5):459-70. doi: 10.1177/000456320103800503.
Epithelial ion channels and transporter proteins have physiologically important roles throughout the length of the nephron. Discovering the molecular identities of tubular epithelial cell proteins and their functional roles has increased understanding of both renal physiology and tubular diseases. Defects in tubular handling of solutes may present with nephrocalcinosis or nephrolithiasis, rickets, acid base, electrolyte or blood pressure disturbances. Biochemical analysis of both serum and urine, together with clinical history and examination, remain fundamental for their diagnosis, whilst understanding of underlying molecular mechanisms allows appropriate management.
上皮离子通道和转运蛋白在整个肾单位中发挥着重要的生理作用。发现肾小管上皮细胞蛋白的分子身份及其功能作用，增进了我们对肾脏生理学和肾小管疾病的理解。肾小管溶质处理缺陷可能表现为肾钙质沉着症或肾结石、佝偻病、酸碱、电解质或血压紊乱。血清和尿液的生化分析，连同临床病史和检查，仍然是诊断这些疾病的基础，而对潜在分子机制的理解有助于进行适当的治疗。
