Collinson P O, Wiggins N, Gaze D C
Department of Chemical Pathology, St George's Hospital, London, UK.
Ann Clin Biochem. 2001 Sep;38(Pt 5):509-19. doi: 10.1177/000456320103800508.
All patients admitted to the coronary care unit with suspected acute coronary syndromes were evaluated by serial electrocardiography and blood draws on admission and at 4 and 12h from admission. Diagnosis was based on conventional WHO criteria. Samples were measured for creatine kinase (CK), cardiac troponin T (cTnT), myoglobin, CK isoenzyme MB (CK-MB) and cardiac troponin I (cTnI). A set of samples from individuals undergoing extreme endurance training was also examined. Analytical imprecision was consistent with published quality goals. Samples were stable for cTnI under a range of storage conditions, including multiple freeze thaw cycles. CK-MB, cTnI and cTnT were equally efficient for the diagnosis of acute myocardial infarction, irrespective of the final diagnostic criteria used. Both cTnI and cTnT were of equal efficiency in the identification of a high-risk subgroup of patients with unstable angina. Significant elevations of cTnI were not seen in an e ndurance-training group.
所有因疑似急性冠脉综合征入住冠心病监护病房的患者，在入院时、入院后4小时和12小时均接受了系列心电图检查和血液检测。诊断依据世界卫生组织的常规标准。对样本进行了肌酸激酶（CK）、心肌肌钙蛋白T（cTnT）、肌红蛋白、CK同工酶MB（CK-MB）和心肌肌钙蛋白I（cTnI）的检测。还对一组进行极限耐力训练的个体的样本进行了检查。分析不精密度符合已发表的质量目标。在一系列储存条件下，包括多次冻融循环，样本中的cTnI都是稳定的。无论使用何种最终诊断标准，CK-MB、cTnI和cTnT在诊断急性心肌梗死方面同样有效。在识别不稳定型心绞痛高危亚组患者方面，cTnI和cTnT的效率相同。耐力训练组未观察到cTnI显著升高。
