Hamlin A, Buller K M, Day T A, Osborne P B
Department of Physiology and Pharmacology, The University of Queensland, Qld 4072, Brisbane, Australia.
Neuropharmacology. 2001 Oct;41(5):574-81. doi: 10.1016/s0028-3908(01)00101-0.
This study examined if brain pathways in morphine-dependent rats are activated by opioid withdrawal precipitated outside the central nervous system. Withdrawal precipitated with a peripherally acting quaternary opioid antagonist (naloxone methiodide) increased Fos expression but caused a more restricted pattern of neuronal activation than systemic withdrawal (precipitated with naloxone which enters the brain). There was no effect on locus coeruleus and significantly smaller increases in Fos neurons were produced in most other areas. However in the ventrolateral medulla (A1/C1 catecholamine neurons), nucleus of the solitary tract (A2/C2 catecholamine neurons), lateral parabrachial nucleus, supramamillary nucleus, bed nucleus of the stria terminalis, accumbens core and medial prefrontal cortex no differences in the withdrawal treatments were detected. We have shown that peripheral opioid withdrawal can affect central nervous system pathways.
本研究考察了吗啡依赖大鼠的脑通路是否会被中枢神经系统外诱发的阿片类药物戒断所激活。用外周作用的季铵类阿片拮抗剂（甲碘化纳洛酮）诱发的戒断增加了Fos表达，但与全身戒断（用可进入脑内的纳洛酮诱发）相比，引起的神经元激活模式更为局限。对蓝斑无影响，在大多数其他区域Fos神经元的增加明显较小。然而，在腹外侧延髓（A1/C1儿茶酚胺神经元）、孤束核（A2/C2儿茶酚胺神经元）、外侧臂旁核、乳头体上核、终纹床核、伏隔核核心和内侧前额叶皮质，未检测到戒断处理之间的差异。我们已经表明，外周阿片类药物戒断可影响中枢神经系统通路。
