三磷酸腺苷（ATP）诱导离体耳蜗Dieters细胞的纤毛运动。

ATP-induced movement of the stalks of isolated cochlear Deiters' cells.

作者信息

Bobbin R P

机构信息

Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Health Sciences Center, 533 Bolivar Street, 5th Floor; New Orleans, LA 70112-2234, USA.

出版信息

Neuroreport. 2001 Sep 17;12(13):2923-6. doi: 10.1097/00001756-200109170-00034.

DOI:10.1097/00001756-200109170-00034

PMID:11588604

Abstract

Deiters' cells, a type of supporting cell in the sensory epithelium of the cochlea, the organ of Corti, have been found to have P2X and P2Y adenosine triphosphate (ATP) receptors on their surfaces. Activation of these receptors may alter the mechanical properties of Deiters' cells and thus of the organ itself. ATP was applied to Deiters' cells isolated from guinea pig cochlea and the tip of the cells' stalk monitored for an ATP induced movement. Application of 100 microM ATP to the cell body of isolated Deiters' cells induced a small, reversible movement of the cells' stalk whereas application of bathing media did not. Results suggest that in vivo endogenous extracellular ATP released from unidentified locations could alter cochlear mechanics.

摘要

代特氏细胞是位于耳蜗（柯蒂氏器）感觉上皮中的一种支持细胞，现已发现其表面存在P2X和P2Y三磷酸腺苷（ATP）受体。这些受体的激活可能会改变代特氏细胞的机械特性，进而改变该器官本身的机械特性。将ATP应用于从豚鼠耳蜗分离出的代特氏细胞，并监测细胞柄尖端因ATP诱导产生的运动。向分离出的代特氏细胞的细胞体施加100微摩尔的ATP会诱导细胞柄产生微小的、可逆的运动，而施加培养液则不会。结果表明，在体内，从不明位置释放的内源性细胞外ATP可能会改变耳蜗的力学特性。