[德国北莱茵-威斯特法伦州科隆行政区的基因研究：DNA-STR系统FGA、TH01、VWA和YNZ22]

[Genetic studies in the Cologne administrative district (North Rhine-Westphalia, Germany): DNA-STR systems FGA, TH01, VWA and YNZ22].

作者信息

Scheil H G, Huckenbeck W, Schuhen S, Schulz S

机构信息

Institut für Humangenetik und Anthropologie, Heinrich-Heine-Universität Düsseldorf.

出版信息

Anthropol Anz. 2001 Sep;59(3):233-42.

PMID:11591050

Abstract

The DNA-STR systems FGA, TH01, VWA, YNZ22 have been studied in two German population samples (Eschweiler, Stolberg and Hürtgenwald, Inden, Langerwehe, administrative area of Cologne, Northrhine-Westphalia). The cluster analysis, including data from Düsseldorf, Germany and from Poland, resulted in a cluster with Eschweiler, Stolberg and Düsseldorf, separating to a certain degree Hürtgenwald, Inden, Langerwehe and Poland more clearly. In contrary to the expectations (based on the history of the migration from Northeastern Europe to Northrhine-Westfalia) and the results of the study of 22 hemogenetic systems (Scheil & Huckenbeck 2000) there was a somewhat larger genetic distance between Eschweiler, Stolberg and Poland than between Hürtgenwald, Inden, Langerwehe and Poland. The combined data of the four STRs and the 22 hemogenetic systems resulted--as expected--in smaller genetic distances between Eschweiler, Stolberg and Poland as well as between Düsseldorf and Poland. These different genetic distances are interpreted as a result of the migration from North-East Europe to North Rhine-Westphalia in the last 130 years and the selective geographic distribution of the migrants in the industrial and urbanised areas.

摘要

DNA-STR系统FGA、TH01、VWA、YNZ22已在两个德国人群样本（埃施韦勒、斯托尔贝格和胡特根瓦尔德、因登、朗格韦厄，科隆行政区，北莱茵-威斯特法伦州）中进行了研究。聚类分析纳入了来自德国杜塞尔多夫和波兰的数据，结果显示埃施韦勒、斯托尔贝格和杜塞尔多夫形成一个聚类，在一定程度上与胡特根瓦尔德、因登、朗格韦厄和波兰更为明显地分开。与预期（基于从东北欧向北莱茵-威斯特法伦州的移民历史）以及对22个血液遗传系统的研究结果（舍尔和胡肯贝克，2000年）相反，埃施韦勒、斯托尔贝格与波兰之间的遗传距离略大于胡特根瓦尔德、因登、朗格韦厄与波兰之间的遗传距离。四个STR和22个血液遗传系统的综合数据——正如预期的那样——显示埃施韦勒、斯托尔贝格与波兰之间以及杜塞尔多夫与波兰之间的遗传距离较小。这些不同的遗传距离被解释为过去130年中从东北欧向北莱茵-威斯特法伦州移民以及移民在工业和城市化地区的选择性地理分布的结果。