部分性癫痫发作期间的心率变化：一项针对新加坡患者的研究。

Heart rate changes during partial seizures: a study amongst Singaporean patients.

作者信息

Wilder-Smith E, Lim S H

机构信息

National University Hospital, Division of Neurology, 5 Lower Kent Ridge Road, 1109074, Sinapore.

出版信息

BMC Neurol. 2001 Dec 18;1:5. doi: 10.1186/1471-2377-1-5.

DOI:10.1186/1471-2377-1-5

PMID:11591224

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC57745/

Abstract

INTRODUCTION

Studies in Europe and America showed that tachycardia, less often bradycardia, frequently accompanied partial seizures in Caucasian patients. We determine frequency, magnitude and type of ictal heart rate changes during partial seizures in non-Caucasian patients in Singapore.

METHODS

Partial seizures recorded during routine EEGs performed in a tertiary hospital between 1995 and 1999 were retrospectively reviewed. All routine EEGs had simultaneous ECG recording. Heart rate before and during seizures was determined and correlated with epileptogenic focus. Differences in heart rate before and during seizures were grouped into 4 types: (1) >10% decrease; (2) -10 to +20% change; (3) 20-50% increase; (3) >50% increase.

RESULTS

Of the total of 37 partial seizures, 18 were left hemisphere (LH), 13 were right hemisphere (RH) and 6 were bilateral (BL) in onset. 51% of all seizures showed no significant change in heart rate (type 2), 22% had moderate sinus tachycardia (type 3), 11% showed severe sinus tachycardia (type 4), while 16% had sinus bradycardia (type 1). Asystole was recorded in one seizure. Apart from having more tachycardia in bilateral onset seizures, there was no correlation between side of ictal discharge and heart rate response. Compared to Caucasian patients, sinus tachycardia was considerably less frequent. Frequency of bradycardia was similar to those recorded in the literature.

CONCLUSIONS

Significant heart rate changes during partial seizures were seen in half of Singaporean patients. Although sinus tachycardia was the most common heart rate change, the frequency was considerably lower compared to Caucasian patients. This might be due to methodological and ethnic differences. Rates of bradycardia are similar to those recorded in the literature.

摘要

引言

欧美地区的研究表明，在白种人患者中，心动过速常伴随部分性癫痫发作，心动过缓则较少见。我们旨在确定新加坡非白种人患者部分性癫痫发作期间发作期心率变化的频率、幅度和类型。

方法

回顾性分析1995年至1999年在一家三级医院进行的常规脑电图检查中记录的部分性癫痫发作。所有常规脑电图检查均同时记录心电图。确定癫痫发作前和发作期间的心率，并与致痫灶相关联。癫痫发作前和发作期间心率的差异分为4种类型：（1）降低>10%；（2）变化-10%至+20%；（3）升高20%-50%；（4）升高>50%。

结果

在总共37次部分性癫痫发作中，18次发作起始于左半球（LH），13次起始于右半球（RH），6次为双侧（BL）起始。所有癫痫发作中51%的心率无显著变化（2型），22%有中度窦性心动过速（3型），11%表现为严重窦性心动过速（4型），而16%有窦性心动过缓（1型）。一次癫痫发作记录到心脏停搏。除双侧起始发作的心动过速较多外，发作期放电部位与心率反应之间无相关性。与白种人患者相比，窦性心动过速的发生率明显较低。心动过缓的频率与文献报道相似。