卵巢储备功能减退患者的生殖结局

Reproductive outcome in patients with diminished ovarian reserve.

作者信息

Levi A J, Raynault M F, Bergh P A, Drews M R, Miller B T, Scott R T

机构信息

Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Fertil Steril. 2001 Oct;76(4):666-9. doi: 10.1016/s0015-0282(01)02017-9.

DOI:10.1016/s0015-0282(01)02017-9

PMID:11591396

Abstract

OBJECTIVE

To compare reproductive outcome between women with normal ovarian reserve and women with abnormal ovarian reserve.

DESIGN

Retrospective.

SETTING

Tertiary care center.

PATIENT(S): Nine thousand eight hundred and two patients who had basal follicle-stimulating hormone (FSH) concentrations measured as part of an infertility evaluation.

INTERVENTION(S): Monitoring of early pregnancy.

MAIN OUTCOME MEASURE(S): Pregnancy loss rates, live birth rates.

RESULT(S): Of 1,034 patients with diminished ovarian reserve (DOR) (FSH > or =14.2 IU/L), 28 (2.7%) conceived. Twenty of these pregnancies (20/28; 71.4%) were lost in the first trimester. Pregnancy loss rates in women with DOR were 57.1% in women <35 years old, 63.5% in women 35-40 years old, and 90.0% in women >40 years old. These rates of pregnancy loss were significantly higher compared to age-matched patients with normal ovarian reserve.

CONCLUSIONS(S): Women with DOR have exceedingly high rates of pregnancy loss, regardless of age. Women with diminished ovarian reserve should be counseled that, in addition to a low probability of conception, live birth rates are poor.

摘要

目的

比较卵巢储备功能正常的女性与卵巢储备功能异常的女性的生殖结局。

设计

回顾性研究。

地点

三级医疗中心。

患者

9802例作为不孕症评估一部分测量了基础促卵泡激素（FSH）浓度的患者。

干预措施

监测早期妊娠。

主要观察指标

流产率、活产率。

结果

在1034例卵巢储备功能减退（DOR）（FSH≥14.2 IU/L）的患者中，28例（2.7%）受孕。其中20例妊娠（20/28；71.4%）在孕早期流产。DOR女性中，年龄<35岁的女性流产率为57.1%，35 - 40岁的女性为63.5%，>40岁的女性为90.0%。与年龄匹配的卵巢储备功能正常的患者相比，这些流产率显著更高。