长寿领域的重复研究：丹麦百岁老人3' APOB-VNTR基因座上令人困惑的发现。

Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus.

作者信息

Varcasia O, Garasto S, Rizza T, Andersen-Ranberg K, Jeune B, Bathum L, Andreev K, Tan Q, Yashin A I, Bonafè M, Franceschi C, De Benedictis G

机构信息

Cell Biology Department, University of Calabria, Rende, Italy.

出版信息

Ann Hum Genet. 2001 Jul;65(Pt 4):371-6. doi: 10.1017/S0003480001008715.

DOI:10.1017/S0003480001008715

PMID:11592926

Abstract

In Danes we replicated the 3'APOB-VNTR gene/longevity association study previously carried out in Italians, by which the Small alleles (less than 35 repeats) had been identified as frailty alleles for longevity. In Danes, neither genotype nor allele frequencies differed between centenarians and 20-64-year-old subjects. However, when Danish and Italian data were compared, a significant difference (p = 0.0004) was found between the frequencies of Small alleles in youths, which disappeared in centenarians (p = 0.290). Furthermore, the demographic-genetic approach revealed in Danes a significant gene-sex interaction relevant to Long alleles (more than 37 repeats). The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history.

摘要

在丹麦人中，我们重复了之前在意大利人身上进行的3'APOB - VNTR基因/长寿关联研究，据此小等位基因（少于35次重复）已被确定为长寿的脆弱等位基因。在丹麦人中，百岁老人与20至64岁的受试者之间的基因型和等位基因频率均无差异。然而，当比较丹麦人和意大利人的数据时，发现年轻人中小等位基因频率存在显著差异（p = 0.0004），而在百岁老人中这种差异消失了（p = 0.290）。此外，人口统计学 - 遗传学方法在丹麦人中揭示了与长等位基因（超过37次重复）相关的显著基因 - 性别相互作用。丹麦和意大利的不同研究结果表明，基因/长寿关联具有人群特异性，并受到特定人群的遗传和环境历史的严重影响。