意大利中部雷卡纳蒂地区D1S80和3'APOB的等位基因及基因型频率

Allele and genotype frequencies for D1S80 and 3'APOB in Recanati, Central Italy.

作者信息

Biondolillo M, Mamolini E, Manni F, Scapoli C, Lorenzetti L, Barrai I

机构信息

Department of Biology, University of Ferrara, Italy.

出版信息

J Forensic Sci. 2000 Sep;45(5):1080-2.

PMID:11005183

Abstract

The VNTR 3'APOB and D1S80 loci were studied in a sample of 179 individuals living in the Recanati Area (Central Italy). For 3'APOB, we found 34 genotypes and 11 alleles. The system was in Hardy-Weinberg equilibrium. The observed and expected heterozygosity were 0.788 and 0.798 respectively. The discrimination power was 0.96, the a-priori paternity exclusion power was 0.619 and the polymorphism information content was 0.773. For D1S80, we found 45 genotypes and 18 alleles. The system deviated significantly from Hardy-Weinberg equilibrium. The observed and expected heterozygosity were 0.696 and 0.790 respectively. The discrimination power was 0.96, the a-priori paternity exclusion power was 0.617 and PIC was 0.767. The Recanati sample was compared with the general Italian frequencies for the 3'APOB locus. A difference of borderline significance was detected (P = 0.04). For D1S80, the sample was compared with a sample from Southern Italy and no significant difference was detected.

摘要

在居住于意大利中部雷卡纳蒂地区的179名个体样本中，研究了VNTR 3'APOB和D1S80基因座。对于3'APOB，我们发现了34种基因型和11个等位基因。该系统处于哈迪-温伯格平衡状态。观察到的杂合度和预期杂合度分别为0.788和0.798。鉴别力为0.96，先验父权排除力为0.619，多态信息含量为0.773。对于D1S80，我们发现了45种基因型和18个等位基因。该系统显著偏离哈迪-温伯格平衡。观察到的杂合度和预期杂合度分别为0.696和0.790。鉴别力为0.96，先验父权排除力为0.617，多态信息含量为0.767。将雷卡纳蒂样本与意大利3'APOB基因座的总体频率进行了比较。检测到边缘显著性差异（P = 0.04）。对于D1S80，将该样本与来自意大利南部的样本进行了比较，未检测到显著差异。