Krezel W, Dupont S, Krust A, Chambon P, Chapman P F
Cardiff School of Biosciences, Cardiff University, Museum Avenue, P.O. Box 911, Cardiff, CF10 3US, United Kingdom.
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12278-82. doi: 10.1073/pnas.221451898. Epub 2001 Oct 2.
Estrogens are powerful modulators of neuronal physiology and in humans may affect a broad range of functions, including reproductive, emotional, and cognitive behaviors. We studied the contribution of estrogen receptors (ERs) in modulation of emotional processes and analyzed the effects of deleting ERalpha or ERbeta in mice. Behavior consistent with increased anxiety was observed principally in ERbeta mutant females and was associated with a reduced threshold for the induction of synaptic plasticity in the basolateral amygdala. Local increase of 5-hydroxytryptamine 1a receptor expression in medial amygdala may contribute to these changes. Our data show that, particularly in females, there is an important role for ERbeta-mediated estrogen signaling in the processing of emotional behavior.
雌激素是神经元生理学的强大调节剂,在人类中可能会影响广泛的功能,包括生殖、情绪和认知行为。我们研究了雌激素受体(ERs)在调节情绪过程中的作用,并分析了敲除小鼠体内ERα或ERβ的影响。主要在ERβ突变雌性小鼠中观察到与焦虑增加一致的行为,并且这与基底外侧杏仁核中突触可塑性诱导阈值的降低有关。内侧杏仁核中5-羟色胺1a受体表达的局部增加可能导致了这些变化。我们的数据表明,特别是在雌性中,ERβ介导的雌激素信号在情绪行为处理中发挥着重要作用。