极低出生体重儿出生后第一周内血细胞比容与出血时间的关系。
The relationship between hematocrit and bleeding time in very low birth weight infants during the first week of life.
作者信息
Sola M C, del Vecchio A, Edwards T J, Suttner D, Hutson A D, Christensen R D
机构信息
Division of Neonatology, Department of Pediatrics, and the General Clinical Research Center, University of Florida College of Medicine, Gainesville, FL 32610-0296, USA.
出版信息
J Perinatol. 2001 Sep;21(6):368-71. doi: 10.1038/sj.jp.7210546.
OBJECTIVES
The bleeding time is a measurement of platelet and capillary interaction following a small standardized cutaneous incision. In adults, anemia causes a prolongation of the bleeding time, and we hypothesized that the same would be true in very low birth weight (VLBW) infants during their first week of life.
STUDY DESIGN
Template bleeding times, using the Surgicutt Newborn device, were performed on 20 VLBW weight infants <or=7 days old, before, and again following a clinically ordered erythrocyte transfusion.
RESULTS
Neonates who had pretransfusion hematocrits <or=0.28 l/l had longer bleeding times, which fell 164+/-25 seconds (mean+/-SD; p<0.0001) following transfusion. Patients with pretransfusion hematocrits >0.28 l/l had no significant reduction in bleeding time following transfusion.
CONCLUSIONS
In VLBW infants, during their first week of life (the time when their risk of intraventricular hemorrhage is greatest), a low hematocrit is associated with a significant prolongation in the bleeding time.
目的
出血时间是在一个小的标准化皮肤切口后对血小板与毛细血管相互作用的一种测量。在成年人中，贫血会导致出血时间延长，我们推测极低出生体重（VLBW）婴儿在出生后第一周情况也是如此。
研究设计
使用Surgicutt新生儿装置，对20名出生7天及以内的VLBW婴儿在临床安排红细胞输血前及输血后进行模板出血时间测定。
结果
输血前血细胞比容≤0.28 l/l的新生儿出血时间较长，输血后出血时间下降了164±25秒（平均值±标准差；p<0.0001）。输血前血细胞比容>0.28 l/l的患者输血后出血时间无显著降低。
结论
在VLBW婴儿出生后的第一周（即其发生脑室内出血风险最高的时期），血细胞比容低与出血时间显著延长有关。
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