新型紫外线宽带滤光剂双-乙基己氧基苯酚甲氧基苯基三嗪(Tinosorb S)对丁基甲氧基二苯甲酰甲烷(阿伏苯宗)和甲氧基肉桂酸乙基己酯的光稳定作用

Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter.

作者信息

Chatelain E, Gabard B

机构信息

Department of Biopharmacy, Spirig Pharma Ltd, CH-4622 Egerkingen, Switzerland.

出版信息

Photochem Photobiol. 2001 Sep;74(3):401-6. doi: 10.1562/0031-8655(2001)074<0401:pobmaa>2.0.co;2.

Abstract

It is now well documented that chronic UVA exposure induces damage to human skin. Therefore, modern sunscreens should not only provide protection from both UVB and UVA radiation but also maintain this protection during the entire period of exposure to the sun. UVA filters, however, are rare and not sufficiently photostable. We investigated the effect of the introduction of a new UV filter, bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), in oil in water sunscreen formulations on the photostability of butyl methoxydibenzoylmethane (Avobenzone [AVB]) after irradiation with an optically filtered Xenon arc source (UV irradiance adjusted at 1 mean effective dose [MED]/min). With spectrophotometrical methods to assess the sun protection factor (SPF) and UVA ratio and chromatographical methods to determine the amount of UV filters recovered after irradiation we showed that Tinosorb S prevented the photodegradation of AVB in a concentration-dependent way, leading to a sustained SPF and UVA ratio even after irradiation with doses of up to 30 MED. Since AVB was shown to destabilize ethylhexyl methoxycinnamate (EHM) we tested the effect of Tinosorb S in sunscreens containing this UV filter combination. Here too Tinosorb S showed photoprotective properties toward both UV filters. Thus, Tinosorb S can be used successfully to improve the photostability and efficiency of sunscreens containing AVB and EHM.

摘要

现已充分证明,长期暴露于UVA会对人体皮肤造成损伤。因此,现代防晒霜不仅应能防护UVB和UVA辐射,还应在整个日照期间保持这种防护效果。然而,UVA滤光剂种类稀少且光稳定性不足。我们研究了在水包油型防晒配方中引入新型UV滤光剂双-乙基己氧基苯酚甲氧基苯基三嗪(Tinosorb S),在用光学滤光氙弧光源照射后(紫外线辐照度调整为1平均有效剂量[MED]/分钟),对丁基甲氧基二苯甲酰甲烷(阿伏苯宗[AVB])光稳定性的影响。通过分光光度法评估防晒系数(SPF)和UVA比值,以及色谱法测定照射后回收的UV滤光剂含量,我们发现Tinosorb S以浓度依赖的方式防止了AVB的光降解,即使在高达30 MED的剂量照射后,仍能保持稳定的SPF和UVA比值。由于已证明AVB会使甲氧基肉桂酸乙基己酯(EHM)不稳定,我们测试了Tinosorb S在含有这种UV滤光剂组合的防晒霜中的效果。在这种情况下,Tinosorb S对两种UV滤光剂均表现出光保护特性。因此,Tinosorb S可成功用于提高含有AVB和EHM的防晒霜的光稳定性和效率。

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