Malone M J, Rosman N P, Szoke M, Davis D
J Neurol Sci. 1975 Sep;26(1):1-11. doi: 10.1016/0022-510x(75)90108-2.
Myelin development has been studied in the neonatally hypothyroid rat brain by isolation and characterization of purified myelin preparations. The hormone deficiency results in a suppression of compact myelin formation and the persistence of a lighter possibly pro-myelin fraction. The appearance of myelin basic protein was markedly delayed in the hormone-deficient animals and this effect on the basic protein moiety may be responsible for the delayed myelinogenesis.
通过分离和鉴定纯化的髓鞘制剂，对新生期甲状腺功能减退大鼠脑内的髓鞘发育进行了研究。激素缺乏导致紧密髓鞘形成受到抑制，较轻的可能是前髓鞘部分持续存在。在激素缺乏的动物中，髓鞘碱性蛋白的出现明显延迟，这种对碱性蛋白部分的影响可能是髓鞘形成延迟的原因。
