钯催化芳基卤化物胺化反应的新氨当量。
New ammonia equivalents for the Pd-catalyzed amination of aryl halides.
作者信息
Huang X, Buchwald S L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2001 Oct 18;3(21):3417-9. doi: 10.1021/ol0166808.
PMID:11594848
Abstract
[reaction: see text]. LiN(SiMe3)2, Ph3SiNH2, and LiNH2 can be be used as ammonia equivalents for the Pd-catalyzed coupling of aryl halides. Using these amine derivatives, simple anilines, including ortho-substituted ones, as well as di- and triarylamines can be readily prepared.
摘要
[反应：见正文]。LiN(SiMe₃)₂、Ph₃SiNH₂和LiNH₂可用作钯催化芳基卤化物偶联反应中的氨等效物。使用这些胺衍生物，可以很容易地制备简单的苯胺，包括邻位取代的苯胺以及二芳基胺和三芳基胺。
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