McDougall N I, Edmunds S E
Department of Gastroenterology, Royal Perth Hospital, Perth, Western Australia, Australia.
J Gastroenterol Hepatol. 2001 Sep;16(9):1051-4. doi: 10.1046/j.1440-1746.2001.02582.x.
Endoscopic stent insertion is the optimum method of palliation for malignant biliary obstruction. Metal stents have several advantages over the polyethylene alternatives, but are significantly more expensive. It has been reported that patients need to survive beyond 6 months to make metal stents more cost-effective. The aim of this study was to audit the performance of expanding metal biliary stents in our endoscopy unit, and to identify factors that might help with patient selection.
The records of all patients who were selected for endoscopic metal stent insertion at the Royal Perth Hospital for malignant biliary obstruction between September 1994 and November 1998 were reviewed.
Thirty-two patients (16 males, mean age 71 years (range 34-88 years) were identified and followed up for a mean 201 days (range 3-810 days). Fifteen (47%) had cholangiocarcinoma, 13 (41%) had pancreatic cancer, and four had metastatic disease as the cause of obstruction. Mortality rates after metal stent insertion were 16, 41 and 55% at 30, 90 and 180 days, respectively. In total, 24 (75%) patients died during the follow-up period. Eleven (34%) stents became obstructed during follow up with a median time to occlusion of 125 days (range 44-729 days). Patients with cholangiocarcinoma had significantly longer survival than pancreatic cancer cases (median 286 vs 58 days, P = 0.04). No other factors were found to correlate with the survival or stent complications.
Less than half of this mixed cohort survived beyond 6 months. Metal stent palliation of malignant biliary obstruction should probably be targeted at those with cholangiocarcinoma, as these patients tend to survive longer.
内镜下支架置入术是恶性胆管梗阻姑息治疗的最佳方法。金属支架相较于聚乙烯支架有诸多优势,但成本要高得多。据报道,患者需存活超过6个月才能使金属支架更具成本效益。本研究的目的是评估我院内镜科扩张式金属胆管支架的性能,并确定有助于患者选择的因素。
回顾了1994年9月至1998年11月在皇家珀斯医院因恶性胆管梗阻而接受内镜下金属支架置入术的所有患者的记录。
共确定32例患者(16例男性,平均年龄71岁(34 - 88岁))并进行了平均201天(3 - 810天)的随访。15例(47%)患有胆管癌,13例(41%)患有胰腺癌,4例因转移性疾病导致梗阻。金属支架置入术后30天、90天和180天的死亡率分别为16%、41%和55%。随访期间共有24例(75%)患者死亡。11例(34%)支架在随访期间发生梗阻,中位梗阻时间为125天(44 - 729天)。胆管癌患者的生存期明显长于胰腺癌患者(中位生存期286天对58天,P = 0.04)。未发现其他因素与生存期或支架并发症相关。
在这个混合队列中,不到一半的患者存活超过6个月。恶性胆管梗阻的金属支架姑息治疗可能应针对胆管癌患者,因为这些患者往往生存期更长。