Price D C, Kaufman L, Pierson R N
J Nucl Med. 1975 Sep;16(9):814-8.
The bromide dilutional volume determined by intravenous administration of 82Br has been compared with the corresponding volume determined by oral administration of stable bromide in 11 patients with various medical disorders. Stable bromide was assayed by fluorescent excitation analysis using a 109Cd source and a lithium-drifted silicon detector. The average deviation between the fluorescent and the radiobromide dilutional volumes was 4.2% with a standard deviation of +/- 8.5%. This substantiates both the accuracy of the fluorescent excitation method as applied to this tracer and the validity of utilizing oral tracer administration in comparison with intravenous administration. The derived estimates of extracellular fluid volume averaged 28.7% of body weight in the entire group of 11 patients and 25.8% in the 4 normal subjects included in the group. Evaluation of the extracellular fluid space utilizing fluorescent excitation of stable bromide permits high statistical accuracy of sample measurement with great simplicity compared with current chemical methods and with avoidance of the patient radiation exposure associated with 82Br.
在11例患有各种疾病的患者中，对通过静脉注射82Br测定的溴化物稀释体积与通过口服稳定溴化物测定的相应体积进行了比较。使用109Cd源和锂漂移硅探测器通过荧光激发分析对稳定溴化物进行测定。荧光法和放射性溴化物稀释体积之间的平均偏差为4.2%，标准差为±8.5%。这证实了应用于该示踪剂的荧光激发法的准确性以及与静脉注射相比口服示踪剂给药的有效性。在整个11例患者组中，细胞外液体积的推导估计值平均为体重的28.7%，在该组中的4名正常受试者中为25.8%。与目前的化学方法相比，利用稳定溴化物的荧光激发来评估细胞外液空间，可使样本测量具有很高的统计准确性，且操作极为简便，同时避免了与82Br相关的患者辐射暴露。
