缺氧诱导因子-1、氧气与三种脯氨酰羟化酶：动物细胞如何向细胞核传递缺氧信号

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

作者信息

Semenza G L

机构信息

McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

出版信息

Cell. 2001 Oct 5;107(1):1-3. doi: 10.1016/s0092-8674(01)00518-9.

DOI:10.1016/s0092-8674(01)00518-9

PMID:11595178

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

摘要

缺氧诱导因子1（HIF-1）是动物细胞和全身氧稳态的全局调节因子。现在已经确定了HIF-1α亚基的氧调节表达的分子基础，为响应细胞氧合变化的基因表达变化提供了一种机制。