在全身缺氧条件下发生的人类肿瘤以及生活在高海拔地区人群中的趋同遗传适应。
Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.
作者信息
Arenillas Carlota, Celada Lucía, Ruiz-Cantador José, Calsina Bruna, Datta Debayan, García-Galea Eduardo, Fasani Roberta, Moreno-Cárdenas Ana Belén, Alba-Linares Juan José, Miranda-Barrio Berta, Martínez-Montes Ángel M, Alvarez-Escola Cristina, Lecumberri Beatriz, González García Ana, K Flores Shahida, Esquivel Emmanuel, Ding Yanli, Peitzsch Mirko, Robles-Guirado José-Ángel, Regojo Zapata Rita Maria, Pozo-Kreilinger José Juan, Iglesias Carmela, Dwight Trisha, Muir Christopher A, Oleaga Amelia, Garrido-Lestache Rodríguez-Monte Maria Elvira, Del Cerro Maria Jesús, Martínez-Bendayán Isaac, Álvarez-González Enol, Cubiella Tamara, Lourenço Delmar Muniz, A Pereira Maria Adelaide, Burnichon Nelly, Buffet Alexandre, Broberg Craig, Dickson Paxton V, Fraga Mario F, Llorente Pendás José Luis, Rueda Soriano Joaquín, Buendía Fuentes Francisco, Toledo Sergio P A, Clifton-Bligh Roderick, Dienstmann Rodrigo, Villanueva Josep, Capdevila Jaume, Gimenez-Roqueplo Anne-Paule, Favier Judith, Nuciforo Paolo, Young William F, Bechmann Nicole, Opotowsky Alexander R, Vaidya Anand, Bancos Irina, Weghorn Donate, Robledo Mercedes, Casteràs Anna, Dos-Subirà Laura, Adameyko Igor, Chiara María-Dolores, Dahia Patricia L M, Toledo Rodrigo A
机构信息
Biomarkers and Clonal Dynamics Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
出版信息
Cancer Discov. 2025 May 2;15(5):1037-1062. doi: 10.1158/2159-8290.CD-24-0943.
This study reveals a broad convergence in genetic adaptation to hypoxia between natural populations and tumors, suggesting that insights from natural populations could enhance our understanding of cancer biology and identify novel therapeutic targets. See related commentary by Lee, p. 875.
这项研究揭示了自然种群与肿瘤在对缺氧的遗传适应方面存在广泛趋同，这表明来自自然种群的见解可能会增进我们对癌症生物学的理解，并确定新的治疗靶点。见李的相关评论，第875页。
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